BOP-Cl CAS 68641-49-6 Peptide Coupling Reagent Purity >99.0% (AT) Factory

Short Description:

Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride

Synonyms: BOP-Cl

CAS: 68641-49-6

Purity: >99.0% (Argentmetric Titration)

White to Off-White Crystalline Powder

Peptide Coupling Reagents, High Quality

Contact: Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Product Detail

Product Tags

Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride (BOP-Cl) (CAS: 68641-49-6) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase BOP-Cl, Please contact: alvin@ruifuchem.com

Chemical Properties:

Chemical Name	Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride
Synonyms	BOP-Cl; N,N-Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride; Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic Chloride; Phosphoric Acid bis(2-oxooxazolidide) Chloride
Stock Status	In Stock, Mass Production
CAS Number	68641-49-6
Molecular Formula	C6H8ClN2O5P
Molecular Weight	254.56 g/mol
Melting Point	190.0~200.0℃
Density	1.71±0.10 g/cm3
Sensitive	Moisture Sensitive
Solubility in N,N-DMF	Almost Transparency
Solubility	Soluble in Dimethylformamide
Storage Temp.	Cool & Dry Place (2~8℃)
COA & MSDS	Available
Category	Coupling Reagents
Brand	Ruifu Chemical

Specifications:

Items	Inspection Standards	Results
Appearance	White to Off-White Crystalline Powder	Complies
Melting Point	190.0~200.0℃	196.0~198.0℃
Loss on Drying	<0.50%	0.12%
Purity / Analysis Method	>99.0% (Argentmetric Titration)	99.5%
Infrared Spectrum	Conforms to Structure	Complies
Proton NMR Spectrum	Conforms to Structure	Complies
Conclusion	The product has been tested & complies with the given specifications

Package/Storage/Shipping:

Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Moisture sensitive. Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture. Store away from oxidizing agent.
Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery.

Advantages:

Sufficient Capacity: Sufficient facilities and technicians

Professional Service: One stop purchasing service

OEM Package: Custom package and label available

Fast Delivery: If within stock, three days delivery guaranteed

Stable Supply: Maintain reasonable stock

Technical Support: Technology solution available

Custom Synthesis Service: Ranged from grams to kilos

High Quality: Established a complete quality assurance system

FAQ:

How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.

Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.

Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.

Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.

Factory Audit? Factory audit welcome. Please make an appointment in advance.

MOQ? No MOQ. Small order is acceptable.

Delivery Time? If within stock, three days delivery guaranteed.

Transportation? By Express (FedEx, DHL), by Air, by Sea.

Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.

Custom Synthesis? Can provide custom synthesis services to best fit your research needs.

Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.

68641-49-6 - Risk and Safety:

Hazard Symbols C - Corrosive
Risk Codes 34 - Causes burns
Safety Description
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S27 - Take off immediately all contaminated clothing.
UN IDs UN 3261 8/PG 2
WGK Germany 3
RTECS SZ5871000
FLUKA BRAND F CODES 10-21
Hazard Class 8
Packing Group II

Application:

Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride (BOP-Cl) (CAS: 68641-49-6), reagents for carboxyl activation and peptide coupling. BOP-Cl was used in the preparation of hexadepsipeptide. Also used as reagent is used for activating the carboxylic group, synthesis of amides, esters and peptides. BOP-Cl is a highly effective reagent for the acylation of N-methyl amino acids. It provides good yields with low epimerization. BOP-Cl is also an efficient reagent for coupling protected amino monothioacids to iminoamino acid residues to form thiopeptide bonds.
BOP-Cl is a phosphoric acid derivative used as a coupling reagent for amide and ester formation. BOP-Cl is effective in the acylation of N-methylated amino acids and in the introduction of thiopeptide bonds on imino acids. BOP-Cl requires mild conditions, gives good yields and suppresses epimerisation. BOP-Cl and other phosphinic acids activate the carboxylic acid by forming a carboxylic-phosphinic mixed anhydride, in which stereochemistry is conveniently retained. BOP-Cl gives good performances in the acylation of N-methylated amino acids due to intramolecular base catalysis.